Master this deck with 16 terms through effective study methods.
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Fibroblast-like synoviocytes (FLS) acquire a tumour-like phenotype and invade cartilage.
They produce rheumatoid factor and autoantibodies, contributing to the immune response.
They mediate bony erosions at the bone-pannus junction, activated by RANKL.
Anti-CCP has a specificity of 95-98%, much higher than RF's 70-80%.
It correlates with more aggressive, erosive joint disease in rheumatoid arthritis.
They can predict erosive disease and may precede clinical onset by years.
Neutrophils predominate in synovial fluid, not forming the invasive pannus tissue.
A negative result does not definitively exclude the diagnosis of RA.
It helps distinguish RA from other causes of early synovitis.
20–30% of RA patients may test negative for anti-CCP and RF.
Folic acid on different days with regular blood monitoring.
To detect myelosuppression and hepatotoxicity risks.
Felty's syndrome.
With sicca symptoms like dry eyes and mouth.
It may reduce methotrexate's antifolate efficacy.
Increased toxicity risk due to reduced methotrexate clearance.