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Failure of chromosomes to separate properly during meiosis.
In Meiosis I, homologous chromosomes fail to separate; in Meiosis II, sister chromatids do not separate.
A condition resulting from gametes with abnormal chromosome numbers fusing.
The resulting zygote will be monosomic for that chromosome.
The zygote has three copies of a chromosome, leading to potential developmental issues.
They occur in 10-25% of all human conceptions.
A condition where cells have more than two complete sets of chromosomes.
They can lead to unbalanced gametes and potential aneuploidy.
Nondisjunction, aneuploidy, deletion, duplication, inversion, translocation.
They can cause abnormal gene dosage affecting development.