Respiratory System

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    Pulmonary ventilation

    The process of inhalation (inflow) and exhalation (outflow) of air - involves the exchange of air between the atmosphere and the alveoli of the lungs.

    External (pulmonary) respiration

    The exchange of gases between the alveoli of the lungs and the blood in pulmonary capillaries across the respiratory membrane. In this process, blood in pulmonary capillaries gain oxygen and loses carbon dioxide.

    Internal (tissue) respiration

    The exchange of gases between blood in systemic capillaries and tissue cells. In this step the blood loses oxygen and gains carbon dioxide.

    Cellular respiration

    The metabolic reactions that consume oxygen and give off carbon dioxide during the production of ATP.

    Nasal conchae (turbinates)

    Projections within the nasal cavity that increase the surface area for conditioning of the air that enters.

    Nasal meatuses

    Air passageways within the nasal cavity.

    Pharynx

    Region of upper respiratory tract that lies just posterior to the nasal and oral cavities.

    Soft palate

    Posterior portion of the roof of the mouth that prevents food and drink from going up into the nasal cavity.

    Eustachian tube

    Equalizes air pressure between the middle ear and the atmosphere.

    Larynx

    Short passageway (aka voice box) that connects the laryngopharynx with the trachea.

    Thyroid cartilage

    Hyaline cartilage that forms the anterior wall of the larynx and gives it a triangular shape.

    Epiglottis

    Elastic cartilage that seals off the larynx during swallowing to prevent food or drink from entering the respiratory tract.

    Cricoid cartilage

    A complete ring of hyaline cartilage that forms the inferior wall of the larynx.

    Cuneiform cartilages

    Wedge-shaped cartilages that support the vocal folds and lateral aspects of the epiglottis.

    Corniculate cartilages

    Horn-shaped pieces of elastic cartilage located at the apex of each arytenoid cartilage.

    Arytenoid cartilages

    Triangular pieces of mostly hyaline cartilage located at the posterior, superior border of the cricoid cartilage.

    Vestibular folds

    Superior folds within the larynx that function in holding the breath against pressure in the thoracic cavity, such as might occur when a person strains to lift a heavy object.

    Vocal folds

    Inferior folds within the larynx that vibrate to produce sound (phonation).

    Trachea

    Tubular passageway that extends from the larynx to the primary bronchi.

    Primary bronchus

    One of the two main air passages that branch from the trachea and convey air towards a lung.

    Secondary bronchi

    Air passages for each lobe of the lungs.

    Tertiary bronchi

    Air passages for each segment of the lungs.

    Terminal bronchioles

    Represent the end of the conducting zone of the respiratory system.

    Conducting zone

    "Zone" of the respiratory tract responsible for moving, warming, filtering, and humidifying air.

    Respiratory zone

    "Zone" of the respiratory tract responsible for gas exchange.

    Parietal pleura

    Layer of the pleura that lines the wall of the thoracic cavity.

    Visceral pleura

    Layer of the pleura that covers the lungs themselves.

    Pleural cavity

    The small space between the visceral and parietal pleurae.

    Respiratory bronchioles

    First portion of the respiratory zone where gas exchange can occur at alveoli that bud from the walls of the bronchiole.

    Alveoli

    Air sacs of the lungs that allow rapid gas exchange.

    Carina

    The point where the trachea divides into right and left main bronchi - the most sensitive area for triggering a cough reflex.

    Respiratory membrane

    The tissue through which gases diffuse between the air in alveoli and the blood in the pulmonary capillaries.

    Type I alveolar cells

    Simple squamous epithelial cells that form the alveolar wall.

    Type II alveolar cells (septal cells)

    Cells that secrete alveolar fluid, which keeps the surface between the cells and the air moist - ncluded in the alveolar fluid is surfactant.

    Surfactant

    a complex mixture of phospholipids and lipoproteins that lowers the surface tension of alveolar fluid, which reduces the tendency of alveoli to collapse.

    Alveolar macrophage (dust cells)

    Phagocytes that remove fine dust particles and other debris from the alveolar spaces.

    Boyle's law

    The pressure of a gas in a closed container is inversely proportional to the volume of the container.

    Diaphragm

    Muscle responsible for about 75% of the air that enters the lungs during quiet breathing.

    External intercostals

    Muscle responsible for about 25% of the air that enters the lungs during normal quiet breathing.

    Internal intercostals and abdominals

    Muscles compress the thoracic cavity during forced exhalation.

    Sternocleidomastoid and scalenes

    Muscles expand thoracic cavity during forced inhalation.

    Intrapleural pressure

    Pressure in the pleural cavity that is always a negative pressure (lower than atmospheric pressure).

    Alveolar (intrapulmonic) pressure

    Pressure in the lungs that is below atmospheric during inhalation and above atmospheric during exhalation.

    Elastic recoil of chest wall and lungs

    Force responsible for normal exhalation during quiet breathing.

    Tidal volume

    Amount of air inhaled or exhaled with each breath under resting conditions.

    Inspiratory reserve volume

    Amount of air that can be forcefully inhaled after a normal tidal volume inhalation

    Expiratory reserve volume

    Amount of air that can be forcefully exhaled after a normal tidal volume exhalation

    Residual volume

    Amount of air remaining in the lungs after forced exhalation

    Inspiratory capacity

    Maximum amount of air that can be inspired after a normal expiration (TV + IRV).

    Functional residual capacity

    Volume of air remaining in the lungs after a normal tidal volume expiration (ERV + RV).

    Vital capacity

    Maximum amount of air that can be expired after a maximum inspiratory effort (TV + IRV + ERV)

    Total lung capacity

    Maximum amount of air contained in lungs (TV + IRV + ERV + RV)

    Dalton's law

    Each gas in a mixture of gases exerts its own pressure as if no other gases were present.

    Bicarbonate ion

    The greatest percentage (70%) of carbon dioxide is transported in the blood as this molecule.

    Bohr effect

    The physiological phenomenon stating that hemoglobin's affinity is inversely related to acidity (increasing acidity = decreasing affinity).

    Carbonic anhydrase

    Enzyme in red blood cells that catalyzes the conversion of carbon dioxide to carbonic acid or carbonic acid back to carbon dioxide.

    2,3-bisphosphoglycerate (BPG)

    Molecule in RBCs produced in response to thyroxine, hGH, Epi, NE, and testosterone (enhances unloading).

    Dorsal respiratory group (DRG)

    Collection of neurons in the medulla oblongata that generate impulses to the diaphragm via the phrenic nerves and the external intercostal muscles via the intercostal nerves

    Ventral respiratory group (VRG)

    Collection of neurons in the medulla oblongata that become activated when forceful breathing is required

    Central chemoreceptors

    Receptors in the medulla oblongata that sense changes in H+ concentration and carbon dioxide in cerebrospinal fluid.

    Peripheral chemoreceptors

    Receptors in the aorta and carotid arteries that sense changes in oxygen, H+, and carbon dioxide levels in the blood.

    Glossopharyngeal and Vagus

    Nerves that contain sensory neurons that monitor chemistry of blood in the carotid arteries and aorta.

    Phrenic and Intercostal

    Nerves that contain motor neurons that stimulate contraction of the diaphragm and external intercostal muscles.